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Chemical Stress Test

(Adenosine Stress Test; Persantine Stress Test; Regadenason (Lexiscan) Stress Test; Dobutamine Stress Test)

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Definition | Reasons for Test | Possible Complications | What to Expect | Call Your Doctor


A stress test is used to make sure the heart muscles are able to get enough blood when the heart rate and workload are increased. To do this, your heart needs to be looked at during a period of rest and then again during a period of increased activity. A chemical stress test uses chemical agents injected into the body through the vein. These chemicals make the heart function as if it were under stress.

There are many different ways to examine the heart during a stress test. The heart can be examined with:

Reasons for Test

A chemical stress test is used when a traditional stress test (called a cardiac stress test) cannot be done. A cardiac stress test requires you to walk on a treadmill or ride a stationary bicycle until your heart rate reaches a level where your heart is "stressed." You may not be able to participate in this test if you have certain conditions, such as:

In this case, a chemical stress test is used. This test is often used to help your doctor:

  • Determine if you have a heart condition causing your chest pain
  • Determine if arteries to the heart have blockages or narrowing ( coronary artery disease [CAD])
  • Identify an irregular heart rhythm
  • Monitor the heart's response to treatment or procedures
  • Plan rehabilitation after a heart attack

Possible Complications

Complications are rare. If you are planning to have this test, your doctor will review a list of possible complications, which may include:

  • Shortness of breath
  • Chest pain
  • Irregular heartbeat
  • Heart attack (rare)

Technicians will be checking for signs of heart or lung problems. They will be prepared to take action right away if complications develop. A cardiologist (heart specialist) will also be available during the test.

What to Expect

Your doctor may do the following:

  • Physical exam
  • Resting electrocardiogram (ECG, EKG)—a test that records the heart's activity by measuring electrical currents through the heart muscle
  • Echocardiogram—a test that uses sound waves (ultrasound) to examine the size, shape, and motion of the heart and the function of its valves
  • Review of your medicines—some may prevent the heart rate from increasing appropriately

Talk with your doctor before the day of the test to discuss how long you should fast (not eat or drink). Your doctor may recommend that you:

  • Do not eat or drink anything with caffeine 12-24 hours before the test.
  • Do not eat or drink anything, except water, four hours before the test.
  • Do not smoke for several hours before the test.
  • Wear comfortable clothing.
  • Bring a list of your current medicines to the test.
  • If you have diabetes, bring your glucose monitor to the test.
  • Tell your doctor if you have asthma or chronic obstructive pulmonary disease (COPD).

You will lie down on a table. A technician will place electrodes on your chest. Your resting blood pressure and ECG readings will be taken. An IV (hollow needle and thin tube) will be placed in your arm. You will be hooked up to a heart monitor that will record your heart’s activity. Your blood pressure and heart rate will be checked often. A small amount of chemical will be injected through the IV and into your body. Depending on which chemical is used, your heart will beat faster and/or the blood vessels near your heart will open wider. An ECG may also be done at this time.

If you have chest pain, trouble breathing, dizziness, or any other symptoms, tell your doctor or technician right away. The test may need to be stopped. Changes in the ECG may also be a reason to stop the test.

If you are getting nuclear imaging, the technician will inject a mildly radioactive chemical through your IV. Thirty to sixty minutes after the chemical injection, a special camera or an MRI will be used to track the flow of the chemical through and around your heart. Images will be taken to find areas of the heart that may not be getting enough blood or are blocked. If you are getting a stress echocardiogram, an ultrasound will be taken at specific time points. The doctor will compare the pictures of your heart under stress with pictures of your heart at rest.

Your blood pressure, heart rate, and ECG will be monitored until levels return to normal. You will be able to leave after the test is done. 

Typically takes 3-4 hours to complete (may be done over 1-2 days)

No, you should not feel pain during the test. You may feel a pinch when the IV is inserted. You may also feel a flushing sensation when the medicine is injected.

Your doctor may discuss some of the results on the same day as the test. It may take 2-3 days for the full results to be ready.

One or more of the following are considered a positive stress test:

  • ECG changes that show low oxygen supply to the heart
  • Significant blood pressure drops or rhythm changes
  • You have chest pain or trouble breathing, especially if linked with ECG changes
  • Stress test pictures that show areas of your heart having low blood flow or abnormal movements

A positive test may mean that you have CAD. Not everyone tests positive for it. Based on your results, your doctor may recommend more tests or care.

Call Your Doctor

After the test, call your doctor if any of the following occurs:

  • Chest pain
  • Shortness of breath
  • Racing or irregular heart beat
  • Dizziness or weakness
  • Any other unusual symptoms or concerns

If you think you have an emergency, call for medical help right away.


American Heart Association


American Society of Nuclear Cardiology


Heart Rhythm Society



Canadian Heart & Stroke Association


Canadian Society of Nuclear Medicine



American Heart Association website. Available at: http://www.americanheart.org/. Accessed November 14, 2009. 

American Society of Nuclear Cardiology website. Available at: http://www.asnc.org/. Published September 23, 2009. Accessed November 14, 2009.

Libby P, Bonow RO, Mann DL, Zipes DP. Exercise stress testing. In: Braunwald E, ed.  Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, PA: WB Saunders; 2007.

Pearson TA, Blair SN, Daniels SR, et al. AHA guidelines for primary prevention of cardiovascular disease and stroke: 2002 update. Circulation. 2002;106:388-391.

Recovery road booklet. Canadian Heart & Stroke website. Available at: http://ww2.heartandstroke.ca/splash/. Published June 11, 2009. Accessed November 14, 2009.

Last reviewed March 2013 by Michael J. Fucci, DO

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

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