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(Hairy Leukoplakia; Smoker’s Keratosis)

Pronounced: lu-kō-plā'kē-ă
En Español (Spanish Version)

Definition | Causes | Risk Factors | Symptoms | Diagnosis | Treatment | Prevention


Leukoplakia is a disorder of the mouth’s mucus membranes. White patches form on the tongue or inside of the mouth over weeks or months. This can also occur on the vulva in females, but for unknown reasons. One type, known as hairy leukoplakia, is a type found primarily in people who have HIV or other types of severe immune deficiency.


Hairy leukoplakia results from infection with the Epstein-Barr virus.

Leukoplakia usually results from irritants, such as:

  • Pipe or cigarette smoking
  • Chewing tobacco or snuff
  • Rough teeth
  • Rough places on dentures, fillings, or crowns

Risk Factors

Leukoplakia is more common in men after 65 years of age. These other risk factors increase your chance of developing leukoplakia. Tell your doctor if you have any of these risk factors:

  • Sex: In women, the condition often develops into cancer.
  • Lifestyle:
    • Tobacco use, especially smokeless tobacco
    • Long-time alcohol use
  • Having a weakened immune system such as from HIV


Symptoms may include:

  • Lesion on the tongue or gums, inside of the cheeks, or on the vulva that is:
    • White, gray, or red in color
    • Thick, slightly raised, or hardened on the surface
  • Sensitivity to touch, heat, or spicy foods
  • Pain or other signs of infection
  • With hairy leukoplakia: painless and fuzzy, white appearance

In some cases, leukoplakia looks like oral thrush, which is an infection also associated with HIV/AIDS and lowered immune function.

Oral Thrush—Resembles Leukoplakia

Copyright © Nucleus Medical Media, Inc.


In most cases, a dentist can diagnose leukoplakia with a mouth exam. To confirm a diagnosis or to check for cancer, an oral brush biopsy may be needed. This involves removing some cells with a small brush. It takes only minutes and is painless. A pathologist then checks these cells for signs of cancer. Sometimes the dentist or oral surgeon uses a scalpel to remove cells after numbing the area.


Talk with your doctor about the best treatment plan for you. Treatment options include:

  • Removing the irritant—Quitting smoking or correcting dental problems often takes care of the problem.
  • Removing patches—If the problem persists, or if signs of cancer are present, your dentist or doctor may need to remove patches of leukoplakia.
  • Taking medication—For hairy leukoplakia, the doctor may prescribe antiviral medicines. Or, a solution to apply to the skin may be prescribed.


To help reduce your chance of getting leukoplakia, take the following steps:

  • If you smoke, quit.
  • Avoid or limit your use of alcohol.
  • See a dentist regularly, especially if you have rough places in your mouth.

American Dental Association


National Institute of Dental and Craniofacial Research



Canadian Dental Association


Canadian Dental Hygienists Association



Hairy leukoplakia. DermNet NZ website. Available at: http://dermnetnz.org/site-age-specific/hairy-leukoplakia.html. Updated May 22, 2013. Accessed September 18, 2013.

Oral hairy leukoplakia. AETC National Resource Center website. Available at: http://www.aids-ed.org/aidsetc?page=cm-525a_ohl. Updated June 2012. Accessed September 18, 2013.

Last reviewed September 2013 by Michael Woods, MD

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

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