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Fibrate Drugs

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Drugs in the fibrate family are used to improve levels of cholesterol and related lipids found in the blood. Fibrates are particularly helpful for individuals with high levels of triglycerides.

Medications in this category include:

  • Clofibrate (Atromid-S)
  • Gemfibrozil (Lopid)
  • Fenofibrate (Tricor)
Possible Helpful Interaction

Fibrate drugs are known to raise homocysteine levels in the blood. High levels of homocycsteine have been associated with increased risk of heart disease, although a direct connection has not been proven.

In a double-blind, placebo controlled trial of 29 men taking fenofibrate, use of the B-vitamins folate (650mcg), vitamin B12 (50mcg) and vitamin B6 (50mg) once daily for 6 weeks restored homocysteine levels to nearly normal values.1

Possible Harmful Interaction

Fibrate drugs are known to increase the "blood thinning" effects of drugs in the warfarin (Coumadin) family. Certain herbs, such as garlic, danshen, devil’s claw, dong quai, papaya, PC-SPES and red clover, may thin the blood in a manner somewhat similar to warfarin. Although no such interactions have yet been reported, it is at least theoretically possible that combined use of these herbs and fibrate drugs could pose a risk of bleeding problems.

Dierkes J, Westphal S, Kunstmann S, et al. Vitamin supplementation can markedly reduce the homocysteine elevation induced by fenofibrate. Atherosclerosis. 2001;158:161-164.

Last reviewed August 2013 by EBSCO CAM Review Board

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.


 
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