THURSDAY, June 10 (HealthDay News) -- The widely used cancer
drug bevacizumab (Avastin) is associated with a more than fourfold
increased risk of severe urinary protein loss, a new review
finds.
This major loss of protein from the kidney into the urine can
lead to significant kidney damage and reduce the effectiveness of
the cancer drug, say the researchers, who are from Stony Brook
University Cancer Center in New York.
The findings, culled from an analysis of 16 studies involving
more than 12,000 cancer patients, suggest that doctors need to
monitor the kidney health of patients being treated with
bevacizumab. The report was released online June 10 in advance of
publication in an upcoming print issue of the
Journal of the American Society of Nephrology.
In the review, 2.2 percent of the patients taking Avastin
experienced severe proteinura, with patients who were taking the
highest doses of the drug facing an even higher risk. Also, the
type of cancer played a role in the risk of kidney trouble, with
kidney cancer patients seeing the greatest risk (10.2 percent).
Bevacizumab belongs to a class of drugs known as angiogenesis
inhibitors, which reduce the formation of new blood vessels around
tumors.
Avastin (bevacizumab), manufactured by Genentech, was recently
approved to treat the most common type of kidney cancer.
In 2009, the U.S. Food and Drug Administration approved the use
of Avastin in concert with interferon-alfa, an immunotherapy drug,
to treat renal cell carcinoma that has spread to other organs in
the body. A phase III trial found that the drug combination
increased progression-free survival time by approximately five
months, compared to use of interferon-alfa alone. The study wasn't
able to determine whether the dual treatment extended patients'
lives, according to the American Cancer Society.
The study did find, however, that patients taking both Avastin
and interferon-alpha were more likely to suffer severe side
effects, including bleeding, high blood pressure, protein in the
urine, fatigue, and weakness, according to the cancer society.
Kidney cancer is the eighth most commonly diagnosed cancer in
the United States. The cancer society estimates that there will be
about 57,760 new cases of kidney cancer in the United States this
year, and about 12,980 people will die from the disease.
More information
The U.S. National Cancer Institute has more about
bevacizumab.