MONDAY, Sept. 27 (HealthDay News) -- Broader use of
cholesterol-lowering statins may be a cost-effective way to prevent
heart attack and stroke, U.S. researchers suggest.
In the study, published online Sept. 27 in the journal
Circulation, the researchers also found that screening for high sensitivity C-reactive protein (CRP) to identify patients who may benefit from statin therapy is only cost-effective in certain cases. Elevated levels of CRP indicate inflammation and suggest an increased risk for heart attack and stroke.
Currently, statin therapy is recommended for high-risk patients
-- those with a 20 percent or greater risk of some type of
cardiovascular event within the next 10 years. But statins may also
benefit people with a lower risk, according to Dr. Mark Hlatky,
professor of health research and policy and of cardiovascular
medicine at Stanford University School of Medicine in Stanford,
Calif., and colleagues.
Hlatky's team set out to determine the cost-effectiveness of
three statin therapy approaches in patients with normal cholesterol
levels and no evidence of heart disease or diabetes: following
current guidelines; conducting CRP screening in patients who don't
meet current statin treatment guidelines and offering statins to
those with elevated CRP levels; and providing statin therapy based
on a patient's cardiovascular risk alone, with no CRP testing.
The researchers analyzed which of the three approaches met the
generally accepted cost-effectiveness threshold of no more than
$50,000 per quality-adjusted life-year. They found that statin
therapy based on cardiovascular risk alone, without CRP testing,
was the most cost-effective strategy.
Initiating statin treatment at lower risk levels -- without CRP
testing -- "would further improve clinical outcomes at acceptable
cost, making it the optimally cost-effective strategy in our
analysis," the researchers wrote in a university news release.
"Ideally, a marker would tell us who will benefit from drug treatment and who will not," Hlatky pointed out in the release. "If a test could give us that information, it would be very cost-effective. But there's not good evidence yet that CRP, or any other test, works that well."
The American Heart Association outlines
lifestyle changes that can reduce the risk of
heart attack and stroke.