TUESDAY, Sept. 28 (HealthDay News) -- When taken shortly after
the onset of symptoms, the antiviral drug Tamiflu seems to have
protected otherwise healthy swine flu patients from contracting
pneumonia during the 2009 H1N1 pandemic, Chinese researchers
Tamiflu may also have shortened the period that patients were
contagious and reduced the duration of their fevers, the research
However, reporting in the Sept. 29 issue of
bmj.com, the study authors stressed that their findings should be interpreted with caution given that the conclusions are based on an after-the-fact analysis and on a pool of patients not uniformly given chest X-rays at the time of illness.
The study team, led by Dr. Weizhong Yang and Dr. Hongjie Yu from
the Chinese Center for Disease Control and Prevention in Beijing,
note that in 2009 the fast-spreading influenza A (H1N1) virus
killed more than 18,000 people in over 200 countries.
Prior research has suggested that patients who take antiviral
medications within two days of experiencing seasonal flu symptoms
may develop a less severe and shorter-lasting illness and may also
reduce their risk for complications.
To gauge to what degree this might be true for healthy patients
with a mild form of H1N1, the research team reviewed the medical
records of nearly 1,300 Chinese patients diagnosed with the
infection in 2009.
The average age of the patients was 20. More than three-quarters
were given Tamiflu within a median of three days following the
onset of symptoms, and 920 of the patients underwent follow-up
Just 12 percent of those X-rayed had signs of pneumonia, the
researchers observed. None of them needed admission for intensive
care, and none required mechanical ventilation.
Even after accounting for age, gender, influenza vaccine and
antibiotic treatment history, the authors concluded that Tamiflu
treatment appeared to offer significant protection against
This protective effect was apparent in all patients who took
Tamiflu, even those who took it more than 48 hours after symptom
onset, but those who took the medication within 48 hours
experienced shorter fevers and were contagious for a shorter
The Chinese team nonetheless called for more follow-up research
to investigate the potential benefits of Tamiflu for swine flu.
For more on swine flu, visit the
for Disease Control and Prevention.