THURSDAY, March 10 (HealthDay News) -- Depression appears to
increase the risk of kidney failure, according to a new study.
Depression was linked to a higher rate of hospitalization for
acute kidney injury (formerly known as acute kidney failure), even
after adjusting for heart disease, inflammatory markers, and
lifestyle factors such as body mass index (BMI), smoking, alcohol
consumption and physical activity, according to the
The study, led by Dr. Willem Kop of the Department of Medical
Psychology and Neuropsychology at the University of Tilburg, the
Netherlands, included 5,785 people in the United States who were
followed for 10 years. At the start of the study, the participants
were 65 years and older and were not on kidney dialysis.
The researchers found that depression was also associated with a
higher prevalence of chronic kidney disease (CKD) at baseline. It
was 20 percent more common in people with chronic kidney disease
than in those without the disease.
The study appears online March 10 in the
Clinical Journal of the American Society of Nephrology.
"People with elevated depressive symptoms have a higher risk of subsequent adverse kidney disease outcomes. This is partially explained by other medical factors related to depression and kidney disease. But the association with depression was stronger in patients who were otherwise healthy compared to those who had co-existing medical disorders such as diabetes or heart disease," the researchers wrote in a journal news release.
The researchers are currently examining factors that may explain
the link between depression and kidney disease and failure. These
could include delays in seeking medical care, the effect that
depression has on the immune and nervous systems, and
miscommunication between patients and doctors.
The U.S. National Institute of Mental Health has more about