MONDAY, Aug. 15 (HealthDay News) -- A traditional Chinese herbal
treatment may reduce fever from H1N1 ("swine flu") influenza just
as well as the prescription medication Tamiflu, a new study
"For thousands of years, Chinese herbs have been used to treat influenza," study co-authors Dr. Chen Wang and Dr. Bin Cao, of Beijing Chao-Yang Hospital, Capital Medical University, in China, said in an email. "The pandemic influenza 2009 gave us the opportunity to evaluate a standard Chinese herb formula" designed to target the flu, they added.
Cao and Wang, who specialize in infectious diseases and clinical
microbiology, said the herbal recipe -- known as
maxingshigan-yinqiaosan (M-Y) -- is easily accessible throughout
China and much less expensive than Tamiflu (oseltamivir).
However, finding the medicine in the United States is difficult,
if not impossible, given that it contains the stimulant ephedra.
The United States has banned or restricted the sale of ephedra
products because of concerns about possible complications, such as
heart attack, stroke and even death, related to its use as a
The authors discuss their findings in the Aug. 16 issue of the
Annals of Internal Medicine.
The 2009 H1N1 ("swine flu") pandemic sparked influenza cases
around the globe, resulting in nearly 18,000 deaths, the authors
Per World Health Organization (WHO) recommendations, in most
instances, Tamiflu was the treatment of choice, where it was
available. However, it is often out of reach in less developed
parts of the world, such as rural China, where traditional herbal
medicines are a likely default treatment.
The M-Y flu preparation is composed of 12 herbs: ephedrae,
zhimu, qinghao, shigao, yinhua, huangqin, chaoxingren, lianqiao,
bohe, zhebeimu, niubangzi and gancao.
To compare the relative effectiveness of M-Y and Tamiflu in
treating H1N1 influenza, the authors focused on 410 previously
healthy patients who were diagnosed with a "very mild" form of the
The men and women were relatively young, with an average age of
19. They were being treated in 11 different medical facilities
across four Chinese provinces during the height of the pandemic,
between July and November of 2009, to prevent spreading the flu,
not because their symptoms were severe.
Within 72 hours of the onset of symptoms, the patients were
assigned to one of four five-day treatment groups. One group was
given 75 milligrams of Tamiflu twice a day in capsule form; a
second group received 200 milliliters of M-Y four times a day in
liquid form; a third group took the same dosages of Tamiflu
and M-Y together; and a fourth group received no
All of the herbs were screened for quality, and the M-Y mixture
was deemed to meet Chinese safety standards.
The results: Both M-Y and Tamiflu were effective at eliminating
fever, whether administered on their own or in combination.
All three approaches helped to resolve fever sooner than no
intervention whatsoever, the authors said, noting it appeared that
fever dissipated fastest when M-Y and Tamiflu were given together.
However, none of the treatment methods appeared to be superior in
terms of overall viral control, and side effects were minimal in
Even though the ephedra-containing herbal is not readily
available in the United States, the M-Y herbal formula is available
in many countries besides China, including Korea, Japan, India and
Germany, the study authors noted.
Duffy MacKay, vice president of scientific and regulatory
affairs at the Council for Responsible Nutrition, which represents
the dietary supplement industry, believes that fears over ephedra's
use as a weight-control agent have overlooked "its more traditional
and much safer" role as a medicine against lung inflammation.
MacKay said that in China, traditional medicine is "seamlessly
integrated" into everyday medical practice.
"Here in the U.S., we do things differently," he said. "We have our prescription drugs on the one hand, and then we have dietary supplements on the other."
But, MacKay continued, "it should also be understood that these
two treatments actually work very differently. Tamiflu works to
stop viral replication. But the herbal formula is working on
symptoms to help people become more comfortable. And those are two
very different goals," he noted.
"So our advice," MacKay added, "is that because H1N1 can be very serious, it's very important to see your doctor. And once you're under the care of your licensed physician there's certainly a lot of things in the world of botanicals that might help."
For more on the flu and traditional medicine, visit the
U.S. National Center for Complementary and