TUESDAY, Oct. 18 (HealthDay News) -- Women do have options when
it comes to treating hot flashes and other symptoms of menopause,
and these still include the short-term use of hormone replacement
therapy using estrogen alone, experts conclude in a new consensus
report.
"Hormone replacement therapy should be considered a very reasonable option for recently menopausal women who have moderate-to-severe hot flashes or night sweats," said Dr. JoAnn E. Manson, chief of the division of preventive medicine at Brigham and Women's Hospital in Boston and the current president of the North American Menopause Society (NAMS).
Hormone replacement therapy (HRT) was widely used up until 2002.
That year, however, the estrogen-plus-progestin arm of the Women's
Health Initiative (WHI) trial was stopped early after women who
took the formulation were found to have an increased risk for heart
disease, strokes, breast cancer and blood clots. Use of HRT
plummeted soon after the news was announced.
However, analysis of the estrogen-only arm from the same trial
showed that younger postmenopausal women who had had a hysterectomy
-- could take estrogen for up to six years without significant
risks.
As a result, the pendulum may be swinging back toward the use of
supplemental estrogen -- in low doses and for short periods of time
-- to relieve some of the symptoms of menopause. So concludes the
new report, which is being released jointly by the International
Menopause Society and the American Society for Reproductive
Medicine.
The report was funded by the International Menopause Society and
is published Oct. 18 -- International Menopause Day -- in the
journal
Climacteric.
According to Manson and colleagues, older women need to be more
proactive when it comes to relieving the symptoms of menopause, and
HRT provides the best results for treating hot flashes and night
sweats. Fully 90 percent of women are symptom-free within three
months of the therapy, the experts said.
Many women will see relief from symptoms and improved quality of
life with estrogen, according to Manson, who is also professor of
medicine at Harvard Medical School, in Boston.
However, "any woman who doesn't have symptoms of hot flashes,
night sweats or other menopausal symptoms is
not a candidate," Manson stressed. Other patients who would
not be considered candidates for HRT are women with a history of
hormone-sensitive cancers such as endometrial or breast cancer
and/or a history of heart attack, stroke or blood clots in their
legs, heart or lungs, she said.
In these cases, antidepressants -- such as the widely used
family of selective serotonin reuptake inhibitors (SSRIs), which
include Celexa, Prozac, Paxil and Zoloft -- might be used.
Alternatively, the anti-seizure drug gabapentin may help relieve
symptoms for some, Manson said.
"There are some non-hormonal prescription medications that are better studied now than they have been in the past and may be very reasonable options, especially for women who are not candidates for hormones or who would prefer a non-hormonal option," she added.
The report also looked at acupuncture, but found that the
evidence to support its use against menopausal symptoms is mixed at
best.
Dr. Lila E. Nachtigall is a professor of obstetrics and
gynecology at New York University Langone Medical Center in New
York City. She agreed that, when used on its own, estrogen can
still be safe and effective in treating the symptoms of
menopause.
"If a woman has symptoms and there is not an absolute contraindication, we should be using estrogen again," she believes. "We use the lowest dose for the shortest period of time that reaches the therapeutic goal." According to Nachtigall, that goal is typically the relief of menopausal symptoms.
Dr. Steven R. Goldstein, a professor of obstetrics and
gynecology at New York University Langone Medical Center in New
York City and the immediate past president of NAMS, concurred. "The
estrogen-only arm of the WHI showed almost none of the harms that
were seen with estrogen-and-progesterone arm," he noted.
However, that arm of WHI got very little attention, he said, and
many younger women who could benefit from estrogen replacement
therapy may not be getting it, Goldstein said.
"You need to look at an individual's family history and personal history, and make the most intelligent decision about their menopause treatments," he said. "There is no question that in general the harm that a lot of people associate with hormone replacement therapy is unfounded and overstated," Goldstein said.
He was much less supportive of so-called "bioidentical" hormonal
therapies, which are made by compounding pharmacies and typically
come from plant sources such as soy. "This is snake oil," Goldstein
said, adding that, in his opinion, most bioidenticals do not have
the proper ingredients in the correct amount.
More information
Find out more about menopause at the
U.S. National Library of Medicine.