WEDNESDAY, Jan. 18 (HealthDay News) -- Antidepressants called
selective serotonin reuptake inhibitors (SSRIs) are associated with
an increased risk of falls in nursing home residents with dementia,
a new study finds.
Researchers in the Netherlands analyzed data about daily
prescription medicine use and falls among 248 nursing home
residents with dementia. The dataset collected between Jan. 1, 2006
and Jan. 1, 2008 included 85,074 person-days.
Antidepressants were used on 13,729 days (16 percent), with
SSRIs used on 11,105 of these days, the investigators found.
A total of 683 falls were experienced by 152 (61.5 percent) of
the 248 nursing home residents, which works out to fall incidence
of 2.9 falls per person-year. Thirty-eight residents had one fall
but 114 had frequent falls.
Injury or death resulted from 220 of the falls: 10 were hip
fractures, 11 were other types of fractures, and 198 were injuries
such as sprains, bruises, swelling and open wounds. One person died
after falling, according to the results.
The researchers found that the risk of having an injury-causing
fall was three times higher for residents taking SSRIs than for
those who didn't take the antidepressants. For example, the
absolute daily risk of a fall was 0.28 percent for an 80-year-old
woman taking a daily dose of an SSRI, compared with 0.09 percent
for a woman the same age who didn't take an SSRI.
Similar increases in risk were found for both women and men of
different ages, according to the study published Jan. 19 in the
British Journal of Clinical Pharmacology.
"Our study also discovered that the risk of an injurious fall increased even more if the residents were also given hypnotic or sedative drugs as sleeping pills," lead author Carolyn Shanty Sterke, who works in the section of geriatric medicine at Erasmus University Medical Center in Rotterdam, said in a journal news release.
Falls are a major issue for nursing home residents with
dementia, and one-third of falls among nursing home residents
result in an injury, the study authors noted.
"Staff in residential homes are always concerned about reducing the chance of people falling and I think we should consider developing new treatment protocols that take into account the increased risk of falling that occurs when you give people SSRIs," Sterke said in the news release.
While the study uncovered an association between injury-causing
falls and SSRI use, it did not prove a cause-and-effect
The U.S. Centers for Disease Control and Prevention has more
falls in nursing homes.