Hartford Hospital

Search for

Corneal Transplant

(Keratoplasty; Penetrating Keratoplasty)

En Español (Spanish Version)

Definition | Reasons for Procedure | Possible Complications | What to Expect | Call Your Doctor


Corneal transplant is a surgical procedure used to replace a portion of a diseased or damaged cornea with a healthy one. The cornea is the clear, outer surface on the front of the eye.

Cornea of the Eye

nucleus factsheet image
Copyright © Nucleus Medical Media, Inc.

Reasons for Procedure

A corneal transplant can correct vision problems caused by infections, injuries, or medical conditions that effect the cornea. It is often recommended for the following:

  • Keratoconus—a thinning and bulging of the cornea that causes blurred vision
  • A cornea scarred from infection or injury
  • Clouding of the cornea
  • Complications of previous eye surgery

Possible Complications

The procedure is highly successful. Severe complications are rare. If you are planning to have a corneal transplant, your doctor will review a list of possible complications, which may include:

  • Rejection of the new cornea—The body’s defense system attacks the new tissue, damaging it.
  • Glaucoma
  • Problems focusing
  • Swelling or detachment of the retina
  • Cataract
  • Infection
  • Bleeding

The operation is most successful for patients who have the following:

  • Keratoconus
  • Corneal scars

It is less successful for those who have corneal infection and severe injury, like a chemical burn.

What to Expect

Your ophthalmologist may do a physical exam and blood tests.

Before the procedure:

  • Talk to your doctor about your medications. Also, discuss any herbs or vitamins you take. You may be asked to stop taking some medications up to one week before the procedure, like:
    • Anti-inflammatory medications
    • Blood thinners
    • Anti-platelet medications
  • Arrange to have someone drive you home.
  • Arrange for help at home after the procedure.
  • Use any eye drops as instructed by your eye surgeon.
  • The day before, do not eat or drink anything after midnight unless told otherwise by your doctor.

Two types of anesthesia can be used during a corneal transplant:

  • Local anesthesia to numb the eye—You will stay awake.
  • General anesthesia —You will be asleep.

The procedure will be done under a surgical microscope. The damaged part of the cornea will be cut out. The new cornea will then be placed in the opening. The new cornea will be fastened with very fine stitches. Finally, a patch and shield will be put over the eye.

There is another technique called Descemet's stripping endothelial keratoplasty (DSEK). DSEK is used for some types of cornea transplants. It may result in shorter recovery time and better vision. With this technique, the doctor removes a much smaller part of the cornea, compared with older procedures.

1-2 hours

Anesthesia prevents pain during surgery. You may have slight soreness for a few days after the procedure. Ask your doctor about medicine to help with the pain.

You will most likely go home after a few hours in the recovery area.

After you leave the hospital, you should rest for the remainder of the day. When you return home after the procedure, do the following to help ensure a smooth recovery:

  • Continue to wear the eye patch until your doctor instructs you to remove it.
  • Use eye drops as prescribed.
  • Wear glasses during the day, and wear a shield to protect your eye at night.
  • Protect your eye from accidental bumps or pokes.
  • Do not rub or press on your eye.
  • Do not swim until allowed by your doctor.
  • Avoid contact sports.
  • Do not drive until your doctor gives you permission.
  • Be sure to follow your doctor's instructions .

Your eye will be checked several times during the following weeks and months. Stitches are usually left in place for at least several months.

Vision may initially be worse than before your surgery before your eye adjusts to the new cornea. It may take several months for it to improve.

Call Your Doctor

After you leave the hospital, contact your doctor if any of the following occurs:

  • Signs of infection, including fever and chills
  • Vision symptoms, including decreased vision, floaters, flashing lights, increased light sensitivity, or loss of peripheral vision
  • Increased eye redness
  • Increased pain
  • Nausea or vomiting

In case of an emergency, call for medical help right away.


Eye Bank Association of America


The National Keratoconus Foundation



The Canadian National Institute for the Blind


Canadian Ophthalmological Society



Corneal surgery. The University of Mississippi Medical Center Department of Ophthalmology Services website. Available at: http://www.umc.edu/education/schools/medicine/clinical_science/ophthalmology/clinical_services(ophthalmology)/corneal_surgery_faq.aspx. Accessed June 27, 2013.

Corneal transplants. Cleveland Clinic website. Available at: http://my.clevelandclinic.org/services/corneal_transplantation/eye_overview.aspx. Accessed June 27, 2013.

Corneal transplants. National Keratoconus Foundation website. Available at: http://www.nkcf.org/corneal-transplants/. Accessed June 27, 2013.

Facts about the cornea and corneal disease. The National Eye Institute at the National Institutes of Health website. Available at: http://www.nei.nih.gov/health/cornealdisease/index.asp. Updated May 2013. Accessed June 27, 2013.

Frequently asked questions. Eye Bank Association of America website. Available at: http://www.restoresight.org/about-us/frequently-asked-questions/. Accessed June 27, 2013.

New advance in cornea transplantation. Duke Health website. Available at: http://www.dukehealth.org/eye_center/health_library/news/new_advance_in_cornea_transplantation. Updated July 10, 2009. Accessed June 27, 2013.

Last reviewed June 2013 by Eric L. Berman, MD; Michael Woods, MD

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.

CreativeChangePowered by: Creative Change, Inc.